Outputs
Publications and updates
GRAIL-HCC outputs
- Protocol · 2026GRAIL-HCC umbrella-review programme. PROSPERO CRD420261432723.
- Article · submittedMapping the meta-analytic evidence on hepatocellular carcinoma treatments: the GRAIL-HCC living evidence and gap map. Vitale A, et al., on behalf of the GRAIL-HCC Collaborative Group. Reference and link will be added on publication.
- Dataset · v10Record-level dataset of the 851 included reviews (Supplementary Data S1). Version DOI 10.5281/zenodo.23963090; all versions: 10.5281/zenodo.23963089.
Conceptual background
- BackgroundVitale A, Cabibbo G, Iavarone M, et al. Personalised management of patients with hepatocellular carcinoma: a multiparametric therapeutic hierarchy concept. Lancet Oncol 2023;24:e312-e322.
- BackgroundVitale A, Cabibbo G, Rimassa L, et al. The concept of "converse therapeutic hierarchy" for patients with hepatocellular carcinoma. Liver Cancer 2025. doi:10.1159/000546360.
- BackgroundVitale A, Romano P, Cillo U, et al. Liver resection vs nonsurgical treatments for patients with early multinodular hepatocellular carcinoma. JAMA Surg 2024;159:881-889.
- BackgroundVitale A, Farinati F, Pawlik TM, et al. The concept of therapeutic hierarchy for patients with hepatocellular carcinoma: a multicenter cohort study. Liver Int 2019;39:1478-1489.
How to cite
Please cite the article and the map version you used:
GRAIL-HCC Collaborative Group. GRAIL-HCC living evidence and gap map of meta-analyses comparing treatments for hepatocellular carcinoma, version v10 (4 November 2026). https://grail-hcc.org. doi:10.5281/zenodo.23963090
Licence: Creative Commons Attribution 4.0 International (CC BY 4.0).
Version history
| Version | Date | Changes |
|---|---|---|
| v10 | 4 November 2026 | First public release. 851 reviews, search to 30 March 2026. Views and figures aligned with the published article (Figures 1–4). |
Next scheduled update: search re-run in March 2027, one year after the baseline search.